increase preventative measures, such as masking, testing or physical distancing.report to CDC, local or regional efforts.notify WHO under the International Health Regulations.Variants of concern might require one or more appropriate public health actions such as: reduced effectiveness of treatments or vaccines, or diagnostic detection failures.significant reduction in neutralization by antibodies generated during previous infection or vaccination.more severe disease (for example, increased hospitalizations or deaths). In addition to the possible attributes of a variant of interest, variants designated as VOC include: Variants may be reclassified as more information becomes available.ĬDC monitors all variants circulating in the United States. They also assess how these changes may affect vaccines, therapeutics, and diagnostics, as well as transmission and severity of disease. This information is shared with local and state public health officials to aid in their decision-making for community-level guidance. A group of experts assess the available data on variant proportion at the national and regional level. The SIG meets regularly to evaluate SARS-CoV-2 variants circulating in the United States and to make recommendations about the classification of variants. This interagency group characterizes emerging variants and monitors their potential impact on vaccines, therapeutics, and diagnostics. Department of Health and Human Services (HHS) established a SARS-CoV-2 Interagency Group (SIG) to enhance coordination among CDC, National Institutes of Health (NIH), Food and Drug Administration (FDA), Biomedical Advanced Research and Development Authority (BARDA), and Department of Defense (DoD). The lineage that results from recombination is called a “recombinant.” This may occur when a person is infected with two variants at the same time.
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